“Major depressive disorder (MDD) contributes to a significant worldwide disease burden, expected to be second only to heart disease by 2050. However, accurate diagnosis has been a historical weakness in clinical psychiatry. (…) Over the past two decades, literature on a growing number of (…) biomarkers for MDD increasingly suggests that MDD patients have significantly different biological profiles compare d to healthy controls. However, difficulty in elucidating their exact relationships within depression pathology renders individual markers inconsistent diagnostic tools.”
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